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九亿彩票平台下载

九亿彩票平台下载

九亿彩票平台下载

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Our first, currently available reaction class facilitates the generation of N-Heterocycles. These include morpholines, piperazines, oxazepanes, diazepanes and more complex spiro and bicyclic structures. A broad scope of structurally and electronically different aldehydes can be readily transformed to the N-heterocycle in a very easy manner following just a 10 min reaction setup.
  • 10 different Heterocycle structures currently available
  • Scale: up to 0.5 mmol
The cartridge contains all reagents and catalysts for the imine formation, cyclisation and purification.
Advantages compared to classical batch chemistry are:
  • Minimise user exposure to toxic tin reagents
  • Multistep reactions completed at the touch of a button
  • High reproducibility
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九亿彩票平台下载

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The second reaction class currently enables a reductive amination process. A larger number of complex amines can be generated easily from aldehydes or ketones and primary or secondary amines. 
The cartridge contains all reagent for the condensation, reduction and purification steps of the process.
  • Scale: up to 0.5 mmol
Advantages compared to classical batch chemistry are:
  • Time-saving – reaction, work up and purification in a single process
  • Automation of routine chemistry to allow more time for technically demanding reactions
  • Generic methods, selected based on reaction partners, minimize need for reaction optimization.

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九亿彩票平台下载

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Since its discovery in 1967, Mitsunobu reaction has got a privileged role in organic synthesis and medicinal chemistry because of its scope, stereoselectivity and mild reaction conditions. Its ability of easily forming carbon-carbon bond through dehydrative coupling of a primary or secondary alcohol with a pronucleophile is sometimes counterbalanced by the formation of byproducts which can plague purification strategies. With the Synple machine Mitsunobu reaction can be run without these drawbacks.
  • Scale: up to 0.5 mmol
  • Applicable to a range of pronucleophiles (phenols, phthalimides, tosylamides, tosylhydrazones).
Avantages compared to classical Mitsunobu batch chemistry are:
  • Only 5-10 working time required to obtain Mitsunobu product.
  • No tedious removal PPh3O necessary.

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The third reaction class enables the formation of PROTACs. Both VHL and CRBN Ligands are available with different lenghts of PEG linkers.
The cartridge contains all reagents for the linking the carbonyl group of a protein binder with the partial PROTAC and components for the purification steps of the process.
  • Scale: up to 0.1 mmol
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九亿彩票平台下载

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九亿彩票平台下载

The fourth reaction class enables the attachemnt of Biotin tags to amines and aldehydes/ketones. Different lenghts of PEG linkers are available. 
The cartridge contains all reagents for the linking the compound of choise to a variety of biotin tags and also includes components for a simple purification step.
  • Scale: up to 0.1 mmol
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九亿彩票平台下载
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九亿彩票平台下载
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九亿彩票平台下载

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九亿彩票平台下载

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九亿彩票平台下载

N-Boc protections are one of the most widely used protection groups used in synthetic chemistry.
The Synple Chem synthesizer offers an easy and fast automated method to Boc-protect
primary and secondary amines with less than 5 min working time and no left-over Boc-Anhydride.
  • Scale: two sizes available; up to 0.5 mmol and up to 1.2 mmol

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九亿彩票平台下载

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九亿彩票平台下载

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Details about two reaction classes can be found in our recent poster:
Are you looking for another chemistry application? Contact us!

九亿彩票平台下载

九亿彩票平台下载

九亿彩票平台下载

Snyple Chem was founded in 2016 as a Spin-off from ETH Zürich. Our mission is to provide easy to use, safe, efficiency-enhancing solutions that represent the future of organic synthesis. 
 

九亿彩票平台下载

Now, alongside the Synple 1 and 2, we have our latest addition - the Synple Unity, a flexible parallel synthesiser.
 

九亿彩票平台下载

No, the cartridges come ready filled with all the reagents and materials required for the reaction, work-up and purification. We can, however, provide custom cartridges for users under certain circumstances.
 

九亿彩票平台下载

The machine itself is tolerant of almost all solvents. The limitation are only related to what is tolerated in terms of the chemistry by each reaction class. More information can be found in our application notes.
 

九亿彩票平台下载

In many cases, co-solvents can be added to help solubiulise poorly soluble starting materials. 
 

九亿彩票平台下载

We provide a scope for each reaction that indicates what is fast reacting and slow reacting. For slower reacting materials we recommend increasing the default reaction time. 

九亿彩票平台下载

With the Synple 1 and Synple 2, only one reaction can be run at a time. The Synple Unity system allows you to build a parallel synthesis system to suit your own needs.
 

九亿彩票平台下载

The machine requires very little maintenance and most of the components, e.g. the lines, connections, vial, are all standard. We are also able to offer service and maintenance contracts.
 

九亿彩票平台下载

Yes! Our Synple 1 machines have been installed with customers since May 2018 and our new Synple 2s have been in use since October 2019.
 

九亿彩票平台下载

At the moment we sell directly across Europe and the UK. We can also sell direct in the US or alternatively use a distributor. In addition, we are in discussions with several distributors across Asia.
 

九亿彩票平台下载

The average lead time for the machine is four weeks. Cartridges can be delivered within the week.

九亿彩票平台下载

This depends on the reaction class and what is tolerated by each particular reaction. In many cases co-solvents can be used to help solubilise the starting material.
 

九亿彩票平台下载

Each method has been pre-optimised to give the best yield and purity across a broad substrate scope. If optimisation is required then we would recommend skipping the purification step and checking the product at the end of the run. If it has not gone to completion, the reaction can be run again.
 

九亿彩票平台下载

This is something we are actively exploring.

九亿彩票平台下载

This is dependant on the reaction class. Each run time includes the reaction, work-up and purification time.
© 2019 Synple Chem AG. All Rights Reserved.
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